Drug interactions
Defibrotide + Ibuprofen
Severity: Major
Defibrotide and Ibuprofen: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Defibrotide has profibrinolytic and antithrombotic activity and may increase bleeding risk when given with drugs that impair platelet function, such as NSAIDs. The combination is generally avoided.
What this interaction means in plain words
Defibrotide and Ibuprofen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Defibrotide belongs to Cardiovascular; Ibuprofen belongs to Musculoskeletal.
Why it happens
Additive effects on hemostasis from defibrotide's profibrinolytic activity and ibuprofen's platelet inhibition.
What to do
Avoid concomitant use of NSAIDs with defibrotide where possible, and monitor for bleeding if it cannot be avoided.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Other interactions of Defibrotide
- Alteplase + Defibrotide Contraindicated
- Apixaban + Defibrotide Contraindicated
- Argatroban + Defibrotide Contraindicated
- Dabigatran etexilate + Defibrotide Contraindicated
- Dalteparin + Defibrotide Contraindicated
- Defibrotide + Edoxaban Contraindicated
Frequently asked questions
Can I take Defibrotide with Ibuprofen?
MediHelp rates the interaction as major. Defibrotide and Ibuprofen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Defibrotide has profibrinolytic and antithrombotic activity and may increase bleeding risk when given with drugs that impair platelet function, such as NSAIDs. The combination is generally avoided.
How serious is the interaction between Defibrotide and Ibuprofen?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use of NSAIDs with defibrotide where possible, and monitor for bleeding if it cannot be avoided.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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