Drug interactions
Defibrotide + Meloxicam
Severity: Moderate
Defibrotide and Meloxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Defibrotide has profibrinolytic and antithrombotic activity and may increase bleeding risk when combined with meloxicam, which inhibits platelet function. Labeling advises against concomitant use with systemic anticoagulants or fibrinolytics, and NSAID caution is reasonable.
What this interaction means in plain words
Defibrotide and Meloxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Defibrotide belongs to Cardiovascular; Meloxicam belongs to Musculoskeletal.
Why it happens
Additive pharmacodynamic effects on hemostasis from defibrotide's antithrombotic action and NSAID platelet inhibition.
What to do
Monitor for signs of bleeding and consider withholding meloxicam during defibrotide therapy, particularly if platelets are low.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Other interactions of Defibrotide
- Alteplase + Defibrotide Contraindicated
- Apixaban + Defibrotide Contraindicated
- Argatroban + Defibrotide Contraindicated
- Dabigatran etexilate + Defibrotide Contraindicated
- Dalteparin + Defibrotide Contraindicated
- Defibrotide + Edoxaban Contraindicated
Frequently asked questions
Can I take Defibrotide with Meloxicam?
MediHelp rates the interaction as moderate. Defibrotide and Meloxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Defibrotide has profibrinolytic and antithrombotic activity and may increase bleeding risk when combined with meloxicam, which inhibits platelet function. Labeling advises against concomitant use with systemic anticoagulants or fibrinolytics, and NSAID caution is reasonable.
How serious is the interaction between Defibrotide and Meloxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding and consider withholding meloxicam during defibrotide therapy, particularly if platelets are low.
What other medicines interact with Meloxicam?
MediHelp also lists interactions of Meloxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meloxicam page.
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