Drug interactions
Defibrotide + Tolmetin
Severity: Moderate
Defibrotide and Tolmetin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Defibrotide has profibrinolytic and antithrombotic activity and may enhance the effect of drugs that impair hemostasis. Combined with an NSAID that inhibits platelets, bleeding risk may rise.
What this interaction means in plain words
Defibrotide and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Defibrotide belongs to Cardiovascular; Tolmetin belongs to Musculoskeletal.
Why it happens
Additive pharmacodynamic effect on hemostasis; defibrotide is labeled against concomitant systemic anticoagulants or fibrinolytics, and NSAID antiplatelet action adds to this.
What to do
Review the need for the NSAID during defibrotide therapy and prefer a non-NSAID analgesic. Monitor for signs of bleeding and platelet count if used together.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Other interactions of Defibrotide
- Alteplase + Defibrotide Contraindicated
- Apixaban + Defibrotide Contraindicated
- Argatroban + Defibrotide Contraindicated
- Dabigatran etexilate + Defibrotide Contraindicated
- Dalteparin + Defibrotide Contraindicated
- Defibrotide + Edoxaban Contraindicated
Frequently asked questions
Can I take Defibrotide with Tolmetin?
MediHelp rates the interaction as moderate. Defibrotide and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Defibrotide has profibrinolytic and antithrombotic activity and may enhance the effect of drugs that impair hemostasis. Combined with an NSAID that inhibits platelets, bleeding risk may rise.
How serious is the interaction between Defibrotide and Tolmetin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review the need for the NSAID during defibrotide therapy and prefer a non-NSAID analgesic. Monitor for signs of bleeding and platelet count if used together.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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