Drug interactions
Deflazacort + Dopamine
Severity: Moderate
Deflazacort and Dopamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both corticosteroids such as deflazacort and catecholamines like dopamine can lower serum potassium, so combined use in a critically ill patient may contribute to hypokalemia. Low potassium raises the risk of arrhythmias, particularly in patients receiving a vasopressor with arrhythmogenic potential.
What this interaction means in plain words
Deflazacort and Dopamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Dopamine belongs to Cardiovascular.
Why it happens
Deflazacort has mineralocorticoid-related potassium wasting, while dopamine promotes beta-2 mediated intracellular potassium shift and renal effects, producing additive hypokalemia.
What to do
Monitor serum potassium and ECG during dopamine infusion in patients on deflazacort. Replace potassium to maintain normal levels.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dopamine
- Dihydroergotamine intranasal + Dopamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dopamine + Selegiline transdermal Contraindicated
- Amitriptyline + Dopamine Major
- Clomipramine + Dopamine Major
- Desipramine + Dopamine Major
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Dopamine?
MediHelp rates the interaction as moderate. Deflazacort and Dopamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both corticosteroids such as deflazacort and catecholamines like dopamine can lower serum potassium, so combined use in a critically ill patient may contribute to hypokalemia. Low potassium raises the risk of arrhythmias, particularly in patients receiving a vasopressor with arrhythmogenic potential.
How serious is the interaction between Deflazacort and Dopamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and ECG during dopamine infusion in patients on deflazacort. Replace potassium to maintain normal levels.
What other medicines interact with Dopamine?
MediHelp also lists interactions of Dopamine with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Selegiline transdermal. The full list is on the Dopamine page.
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