Drug interactions
Deflazacort + Erythromycin lactobionate
Severity: Moderate
Deflazacort and Erythromycin lactobionate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intravenous erythromycin inhibits CYP3A4 and can raise exposure to 21-desacetyl deflazacort, the active metabolite of deflazacort. Higher levels increase the risk of corticosteroid adverse effects such as hyperglycemia, fluid retention, mood changes and infection.
What this interaction means in plain words
Deflazacort and Erythromycin lactobionate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Erythromycin lactobionate belongs to Anti Bacterial.
Why it happens
Moderate CYP3A4 inhibition (and possible P-glycoprotein inhibition) by erythromycin reduces clearance of the active deflazacort metabolite.
What to do
Reduce the deflazacort dose to about one-third of the usual dose while a moderate CYP3A4 inhibitor is given, per labeling. Monitor for signs of glucocorticoid excess and restore the dose after the inhibitor is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Other interactions of Erythromycin lactobionate
- Cisapride + Erythromycin lactobionate Contraindicated
- Dihydroergotamine + Erythromycin lactobionate Contraindicated
- Dronedarone + Erythromycin lactobionate Contraindicated
- Eletriptan + Erythromycin lactobionate Contraindicated
- Ergotamine + Erythromycin lactobionate Contraindicated
- Erythromycin lactobionate + Flibanserin Contraindicated
Frequently asked questions
Can I take Deflazacort with Erythromycin lactobionate?
MediHelp rates the interaction as moderate. Deflazacort and Erythromycin lactobionate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Intravenous erythromycin inhibits CYP3A4 and can raise exposure to 21-desacetyl deflazacort, the active metabolite of deflazacort. Higher levels increase the risk of corticosteroid adverse effects such as hyperglycemia, fluid retention, mood changes and infection.
How serious is the interaction between Deflazacort and Erythromycin lactobionate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the deflazacort dose to about one-third of the usual dose while a moderate CYP3A4 inhibitor is given, per labeling. Monitor for signs of glucocorticoid excess and restore the dose after the inhibitor is stopped.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
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