Drug interactions
Deflazacort + Fedratinib
Severity: Moderate
Deflazacort and Fedratinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib is a moderate CYP3A4 inhibitor and may increase exposure to the active metabolite of deflazacort. This can intensify corticosteroid adverse effects such as hyperglycemia, fluid retention and infection.
What this interaction means in plain words
Deflazacort and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Fedratinib belongs to Oncology.
Why it happens
Fedratinib inhibits CYP3A4, reducing the metabolic clearance of the active deflazacort metabolite.
What to do
Reduce the deflazacort dose to about one-third of the usual dose during coadministration, consistent with guidance for moderate CYP3A4 inhibitors. Monitor for glucocorticoid excess.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Deflazacort with Fedratinib?
MediHelp rates the interaction as moderate. Deflazacort and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib is a moderate CYP3A4 inhibitor and may increase exposure to the active metabolite of deflazacort. This can intensify corticosteroid adverse effects such as hyperglycemia, fluid retention and infection.
How serious is the interaction between Deflazacort and Fedratinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the deflazacort dose to about one-third of the usual dose during coadministration, consistent with guidance for moderate CYP3A4 inhibitors. Monitor for glucocorticoid excess.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
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