Drug interactions
Deflazacort + Glipizide
Severity: Moderate
Deflazacort and Glipizide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deflazacort is a glucocorticoid that raises blood glucose and can reduce the effectiveness of glipizide. Higher doses or prolonged courses are more likely to cause loss of glycemic control.
What this interaction means in plain words
Deflazacort and Glipizide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Glipizide belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: glucocorticoids increase hepatic gluconeogenesis and insulin resistance.
What to do
Monitor blood glucose when starting or increasing deflazacort and adjust antidiabetic therapy as needed. Watch for hypoglycemia when the steroid is tapered.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Glipizide?
MediHelp rates the interaction as moderate. Deflazacort and Glipizide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deflazacort is a glucocorticoid that raises blood glucose and can reduce the effectiveness of glipizide. Higher doses or prolonged courses are more likely to cause loss of glycemic control.
How serious is the interaction between Deflazacort and Glipizide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or increasing deflazacort and adjust antidiabetic therapy as needed. Watch for hypoglycemia when the steroid is tapered.
What other medicines interact with Glipizide?
MediHelp also lists interactions of Glipizide with, for example, Disopyramide, Fluconazole, Insulin degludec-liraglutide. The full list is on the Glipizide page.
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