Drug interactions
Deflazacort + Hydrochlorothiazide-irbesartan
Severity: Moderate
Deflazacort and Hydrochlorothiazide-irbesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deflazacort is a corticosteroid and hydrochlorothiazide is a potassium-wasting diuretic, so combined use can cause additive hypokalemia. This is more relevant with long-term or high-dose steroid use and may also promote fluid retention that counteracts antihypertensive therapy.
What this interaction means in plain words
Deflazacort and Hydrochlorothiazide-irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Hydrochlorothiazide-irbesartan belongs to Cardiovascular.
Why it happens
Additive renal potassium loss from thiazide-induced distal sodium delivery and corticosteroid mineralocorticoid activity.
What to do
Monitor serum potassium and blood pressure periodically and replace potassium as needed. The irbesartan component may partly offset potassium loss.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Hydrochlorothiazide-irbesartan?
MediHelp rates the interaction as moderate. Deflazacort and Hydrochlorothiazide-irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deflazacort is a corticosteroid and hydrochlorothiazide is a potassium-wasting diuretic, so combined use can cause additive hypokalemia. This is more relevant with long-term or high-dose steroid use and may also promote fluid retention that counteracts antihypertensive therapy.
How serious is the interaction between Deflazacort and Hydrochlorothiazide-irbesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and blood pressure periodically and replace potassium as needed. The irbesartan component may partly offset potassium loss.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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