Drug interactions
Deflazacort + Idelalisib
Severity: Major
Deflazacort and Idelalisib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib is a strong CYP3A4 inhibitor and increases exposure to the active metabolite of deflazacort. This raises the risk of corticosteroid toxicity and infection in a patient already at risk from idelalisib.
What this interaction means in plain words
Deflazacort and Idelalisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Deflazacort belongs to Miscellaneous; Idelalisib belongs to Oncology.
Why it happens
Strong CYP3A4 inhibition by idelalisib reduces clearance of deflazacort's active metabolite.
What to do
Reduce deflazacort to one-third of the usual dose during coadministration. Monitor for glucocorticoid excess and infection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Deflazacort with Idelalisib?
MediHelp rates the interaction as major. Deflazacort and Idelalisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Idelalisib is a strong CYP3A4 inhibitor and increases exposure to the active metabolite of deflazacort. This raises the risk of corticosteroid toxicity and infection in a patient already at risk from idelalisib.
How serious is the interaction between Deflazacort and Idelalisib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce deflazacort to one-third of the usual dose during coadministration. Monitor for glucocorticoid excess and infection.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
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