Drug interactions
Deflazacort + Metolazone
Severity: Moderate
Deflazacort and Metolazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs promote potassium loss, so combined use can produce hypokalemia. Corticosteroid sodium and fluid retention may also reduce the diuretic effect.
What this interaction means in plain words
Deflazacort and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Metolazone belongs to Cardiovascular.
Why it happens
Additive renal potassium wasting from thiazide-like diuresis and glucocorticoid mineralocorticoid activity.
What to do
Monitor serum potassium and magnesium periodically and supplement as needed. Watch for edema and blood pressure changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metolazone
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Metolazone?
MediHelp rates the interaction as moderate. Deflazacort and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs promote potassium loss, so combined use can produce hypokalemia. Corticosteroid sodium and fluid retention may also reduce the diuretic effect.
How serious is the interaction between Deflazacort and Metolazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium periodically and supplement as needed. Watch for edema and blood pressure changes.
What other medicines interact with Metolazone?
MediHelp also lists interactions of Metolazone with, for example, Amifostine, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide. The full list is on the Metolazone page.
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