Drug interactions
Deflazacort + Ozanimod
Severity: Moderate
Deflazacort and Ozanimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod lowers circulating lymphocyte counts and deflazacort suppresses immune responses, so combined use may increase the risk of infection. The lymphocyte effects of ozanimod persist for some time after it is stopped.
What this interaction means in plain words
Deflazacort and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Ozanimod belongs to Central Nervous System.
Why it happens
Additive immunosuppression through sphingosine-1-phosphate receptor-mediated lymphocyte sequestration and glucocorticoid effects.
What to do
Monitor for infection, and review the lymphocyte count when the combination is prolonged. Keep corticosteroid doses and duration to the minimum needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Deflazacort with Ozanimod?
MediHelp rates the interaction as moderate. Deflazacort and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ozanimod lowers circulating lymphocyte counts and deflazacort suppresses immune responses, so combined use may increase the risk of infection. The lymphocyte effects of ozanimod persist for some time after it is stopped.
How serious is the interaction between Deflazacort and Ozanimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for infection, and review the lymphocyte count when the combination is prolonged. Keep corticosteroid doses and duration to the minimum needed.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
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