Drug interactions
Deflazacort + Stiripentol
Severity: Moderate
Deflazacort and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol affects CYP3A4 in both directions, so deflazacort exposure could change unpredictably. Effects could include loss of steroid efficacy or excess steroid adverse effects.
What this interaction means in plain words
Deflazacort and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol has mixed CYP3A4 inhibitory and inducing effects on deflazacort's active metabolite clearance.
What to do
Monitor clinical response and corticosteroid adverse effects when stiripentol is started or stopped. Adjust the deflazacort dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Deflazacort with Stiripentol?
MediHelp rates the interaction as moderate. Deflazacort and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol affects CYP3A4 in both directions, so deflazacort exposure could change unpredictably. Effects could include loss of steroid efficacy or excess steroid adverse effects.
How serious is the interaction between Deflazacort and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and corticosteroid adverse effects when stiripentol is started or stopped. Adjust the deflazacort dose as needed.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
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