Drug interactions
Degarelix + Dolasetron
Severity: Moderate
Degarelix and Dolasetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation therapy such as degarelix can prolong the QT interval, and dolasetron adds to this effect. The combination may increase the risk of torsades de pointes in patients with cardiac risk factors.
What this interaction means in plain words
Degarelix and Dolasetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Degarelix belongs to Endocrine; Dolasetron belongs to Gastrointestinal Tract.
Why it happens
Additive QT prolongation.
What to do
Check baseline ECG and electrolytes and monitor in patients with cardiac disease. Consider an alternative antiemetic with less QT effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Other interactions of Degarelix
- Degarelix + Pimozide Contraindicated
- Degarelix + Thioridazine Contraindicated
- Amiodarone + Degarelix Major
- Amisulpride + Degarelix Major
- Anagrelide + Degarelix Major
- Cisapride + Degarelix Major
Frequently asked questions
Can I take Degarelix with Dolasetron?
MediHelp rates the interaction as moderate. Degarelix and Dolasetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation therapy such as degarelix can prolong the QT interval, and dolasetron adds to this effect. The combination may increase the risk of torsades de pointes in patients with cardiac risk factors.
How serious is the interaction between Degarelix and Dolasetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and electrolytes and monitor in patients with cardiac disease. Consider an alternative antiemetic with less QT effect.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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