Drug interactions
Degarelix + Goserelin
Severity: Minor
Degarelix and Goserelin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are androgen-deprivation agents acting on the GnRH axis, so using them together is duplicate therapy. Androgen deprivation can prolong the QT interval, so any added QT risk is theoretical.
What this interaction means in plain words
Degarelix and Goserelin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Degarelix belongs to Endocrine; Goserelin belongs to Endocrine.
Why it happens
Duplicate testosterone suppression with theoretical additive QT effect.
What to do
Avoid concurrent use of the two agents and select one. When switching, obtain a baseline ECG and check electrolytes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Goserelin
Other interactions of Degarelix
- Degarelix + Pimozide Contraindicated
- Degarelix + Thioridazine Contraindicated
- Amiodarone + Degarelix Major
- Amisulpride + Degarelix Major
- Anagrelide + Degarelix Major
- Cisapride + Degarelix Major
Frequently asked questions
Can I take Degarelix with Goserelin?
MediHelp rates the interaction as minor. Degarelix and Goserelin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both are androgen-deprivation agents acting on the GnRH axis, so using them together is duplicate therapy. Androgen deprivation can prolong the QT interval, so any added QT risk is theoretical.
How serious is the interaction between Degarelix and Goserelin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of the two agents and select one. When switching, obtain a baseline ECG and check electrolytes.
What other medicines interact with Goserelin?
MediHelp also lists interactions of Goserelin with, for example, Amisulpride, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Goserelin page.
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