Drug interactions
Degarelix + Hydroxychloroquine
Severity: Moderate
Degarelix and Hydroxychloroquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation therapy such as degarelix can prolong the QT interval, and hydroxychloroquine adds further QT risk. The combination may increase the chance of arrhythmia, particularly in older patients with cardiac risk factors.
What this interaction means in plain words
Degarelix and Hydroxychloroquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Degarelix belongs to Endocrine; Hydroxychloroquine belongs to Musculoskeletal.
Why it happens
Additive QT prolongation; degarelix effect arises from androgen suppression.
What to do
Obtain a baseline ECG and correct electrolytes before combining. Monitor the QTc periodically and consider an alternative to hydroxychloroquine if the QTc becomes significantly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxychloroquine
- Arsenic trioxide + Hydroxychloroquine Contraindicated
- Cisapride + Hydroxychloroquine Contraindicated
- Dronedarone + Hydroxychloroquine Contraindicated
- Hydroxychloroquine + Pimozide Contraindicated
- Hydroxychloroquine + Thioridazine Contraindicated
- Hydroxychloroquine + Vandetanib Contraindicated
Other interactions of Degarelix
- Degarelix + Pimozide Contraindicated
- Degarelix + Thioridazine Contraindicated
- Amiodarone + Degarelix Major
- Amisulpride + Degarelix Major
- Anagrelide + Degarelix Major
- Cisapride + Degarelix Major
Frequently asked questions
Can I take Degarelix with Hydroxychloroquine?
MediHelp rates the interaction as moderate. Degarelix and Hydroxychloroquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation therapy such as degarelix can prolong the QT interval, and hydroxychloroquine adds further QT risk. The combination may increase the chance of arrhythmia, particularly in older patients with cardiac risk factors.
How serious is the interaction between Degarelix and Hydroxychloroquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct electrolytes before combining. Monitor the QTc periodically and consider an alternative to hydroxychloroquine if the QTc becomes significantly prolonged.
What other medicines interact with Hydroxychloroquine?
MediHelp also lists interactions of Hydroxychloroquine with, for example, Arsenic trioxide, Cisapride, Dronedarone. The full list is on the Hydroxychloroquine page.
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