Drug interactions
Degarelix + Indacaterol
Severity: Moderate
Degarelix and Indacaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation therapy with degarelix can prolong the QT interval, and indacaterol may add to this effect through its cardiac stimulation and potassium-lowering action. The result may be a higher risk of ventricular arrhythmia in susceptible patients.
What this interaction means in plain words
Degarelix and Indacaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Degarelix belongs to Endocrine; Indacaterol belongs to Respiratory.
Why it happens
Additive pharmacodynamic QT prolongation, with possible beta-2 agonist induced hypokalemia.
What to do
Check a baseline ECG and electrolytes in patients with cardiac risk factors. Correct hypokalemia and hypomagnesemia and monitor the ECG during concurrent use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol
Other interactions of Degarelix
- Degarelix + Pimozide Contraindicated
- Degarelix + Thioridazine Contraindicated
- Amiodarone + Degarelix Major
- Amisulpride + Degarelix Major
- Anagrelide + Degarelix Major
- Cisapride + Degarelix Major
Frequently asked questions
Can I take Degarelix with Indacaterol?
MediHelp rates the interaction as moderate. Degarelix and Indacaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation therapy with degarelix can prolong the QT interval, and indacaterol may add to this effect through its cardiac stimulation and potassium-lowering action. The result may be a higher risk of ventricular arrhythmia in susceptible patients.
How serious is the interaction between Degarelix and Indacaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes in patients with cardiac risk factors. Correct hypokalemia and hypomagnesemia and monitor the ECG during concurrent use.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
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