Drug interactions
Degarelix + Mirtazapine
Severity: Moderate
Degarelix and Mirtazapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation therapy such as degarelix can prolong the QT interval, and mirtazapine has also been linked to QT prolongation. Combined use may increase the risk of arrhythmia, especially with cardiac disease or electrolyte abnormalities.
What this interaction means in plain words
Degarelix and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Degarelix belongs to Endocrine; Mirtazapine belongs to Central Nervous System.
Why it happens
Additive QT prolongation, with degarelix effect mediated by androgen deprivation.
What to do
Consider a baseline ECG and periodic QTc monitoring. Correct electrolyte abnormalities and avoid other QT-prolonging drugs where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Other interactions of Degarelix
- Degarelix + Pimozide Contraindicated
- Degarelix + Thioridazine Contraindicated
- Amiodarone + Degarelix Major
- Amisulpride + Degarelix Major
- Anagrelide + Degarelix Major
- Cisapride + Degarelix Major
Frequently asked questions
Can I take Degarelix with Mirtazapine?
MediHelp rates the interaction as moderate. Degarelix and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation therapy such as degarelix can prolong the QT interval, and mirtazapine has also been linked to QT prolongation. Combined use may increase the risk of arrhythmia, especially with cardiac disease or electrolyte abnormalities.
How serious is the interaction between Degarelix and Mirtazapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a baseline ECG and periodic QTc monitoring. Correct electrolyte abnormalities and avoid other QT-prolonging drugs where possible.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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