Drug interactions
Degarelix + Ondansetron
Severity: Moderate
Degarelix and Ondansetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation therapy such as degarelix can prolong the QT interval, and ondansetron adds to this effect. The combination may increase the risk of torsades de pointes.
What this interaction means in plain words
Degarelix and Ondansetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Degarelix belongs to Endocrine; Ondansetron belongs to Gastrointestinal Tract.
Why it happens
Additive QT prolongation; androgen deprivation alters cardiac repolarization.
What to do
Check a baseline ECG and electrolytes and limit ondansetron to the lowest effective dose. Use an alternative antiemetic in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Other interactions of Degarelix
- Degarelix + Pimozide Contraindicated
- Degarelix + Thioridazine Contraindicated
- Amiodarone + Degarelix Major
- Amisulpride + Degarelix Major
- Anagrelide + Degarelix Major
- Cisapride + Degarelix Major
Frequently asked questions
Can I take Degarelix with Ondansetron?
MediHelp rates the interaction as moderate. Degarelix and Ondansetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation therapy such as degarelix can prolong the QT interval, and ondansetron adds to this effect. The combination may increase the risk of torsades de pointes.
How serious is the interaction between Degarelix and Ondansetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes and limit ondansetron to the lowest effective dose. Use an alternative antiemetic in patients with other QT risk factors.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Thioridazine, Vandetanib. The full list is on the Ondansetron page.
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