Drug interactions
Degarelix + Sotalol
Severity: Major
Degarelix and Sotalol: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation therapy such as degarelix can prolong the QT interval, which adds to the effect of sotalol. This raises the risk of torsades de pointes, especially in patients with other risk factors.
What this interaction means in plain words
Degarelix and Sotalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Degarelix belongs to Endocrine; Sotalol belongs to Cardiovascular.
Why it happens
Additive QT prolongation; androgen deprivation alters cardiac repolarisation.
What to do
Weigh the benefit carefully and monitor ECG and electrolytes. Consider an alternative antiarrhythmic if QTc is prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Other interactions of Degarelix
- Degarelix + Pimozide Contraindicated
- Degarelix + Thioridazine Contraindicated
- Amiodarone + Degarelix Major
- Amisulpride + Degarelix Major
- Anagrelide + Degarelix Major
- Cisapride + Degarelix Major
Frequently asked questions
Can I take Degarelix with Sotalol?
MediHelp rates the interaction as major. Degarelix and Sotalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Androgen deprivation therapy such as degarelix can prolong the QT interval, which adds to the effect of sotalol. This raises the risk of torsades de pointes, especially in patients with other risk factors.
How serious is the interaction between Degarelix and Sotalol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Weigh the benefit carefully and monitor ECG and electrolytes. Consider an alternative antiarrhythmic if QTc is prolonged.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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