Drug interactions
Degarelix + Tiotropium-olodaterol
Severity: Moderate
Degarelix and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation therapy with degarelix can prolong the QT interval, and olodaterol may add to arrhythmia risk through sympathetic stimulation and hypokalemia. The overall risk is modest but relevant in patients with heart disease.
What this interaction means in plain words
Degarelix and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Degarelix belongs to Endocrine; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive effects on cardiac repolarization together with beta2-mediated sympathetic stimulation.
What to do
Consider baseline and periodic ECG in patients with cardiac risk factors and correct electrolyte abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Other interactions of Degarelix
- Degarelix + Pimozide Contraindicated
- Degarelix + Thioridazine Contraindicated
- Amiodarone + Degarelix Major
- Amisulpride + Degarelix Major
- Anagrelide + Degarelix Major
- Cisapride + Degarelix Major
Frequently asked questions
Can I take Degarelix with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Degarelix and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation therapy with degarelix can prolong the QT interval, and olodaterol may add to arrhythmia risk through sympathetic stimulation and hypokalemia. The overall risk is modest but relevant in patients with heart disease.
How serious is the interaction between Degarelix and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider baseline and periodic ECG in patients with cardiac risk factors and correct electrolyte abnormalities.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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