Drug interactions
Degarelix + Trazodone
Severity: Moderate
Degarelix and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation therapy with degarelix can prolong the QT interval, and trazodone may add to this effect. The combination increases the risk of ventricular arrhythmia in susceptible patients.
What this interaction means in plain words
Degarelix and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Degarelix belongs to Endocrine; Trazodone belongs to Central Nervous System.
Why it happens
Additive effects on cardiac repolarization.
What to do
Check baseline ECG and electrolytes and monitor periodically, especially in patients with existing cardiac disease. Consider a non-QT-prolonging alternative to trazodone when risk is high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Degarelix
- Degarelix + Pimozide Contraindicated
- Degarelix + Thioridazine Contraindicated
- Amiodarone + Degarelix Major
- Amisulpride + Degarelix Major
- Anagrelide + Degarelix Major
- Cisapride + Degarelix Major
Frequently asked questions
Can I take Degarelix with Trazodone?
MediHelp rates the interaction as moderate. Degarelix and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation therapy with degarelix can prolong the QT interval, and trazodone may add to this effect. The combination increases the risk of ventricular arrhythmia in susceptible patients.
How serious is the interaction between Degarelix and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and electrolytes and monitor periodically, especially in patients with existing cardiac disease. Consider a non-QT-prolonging alternative to trazodone when risk is high.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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