Drug interactions
Delafloxacin + Magnesium
Severity: Moderate
Delafloxacin and Magnesium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral magnesium salts bind delafloxacin in the gut and reduce its absorption, which may lead to subtherapeutic antibiotic levels and treatment failure.
What this interaction means in plain words
Delafloxacin and Magnesium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Delafloxacin belongs to Anti Bacterial; Magnesium belongs to Gastrointestinal Tract.
Why it happens
Chelation of the fluoroquinolone by magnesium divalent cations in the gastrointestinal tract.
What to do
Give oral delafloxacin at least 2 hours before or 6 hours after magnesium-containing products.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Magnesium
- Ciprofloxacin + Magnesium Major
- Magnesium + Pancuronium Major
- Magnesium + Rocuronium Major
- Magnesium + Vecuronium Major
- Amikacin + Magnesium Moderate
- Amphotericin b deoxycholate + Magnesium Moderate
Other interactions of Delafloxacin
- Aluminum hydroxide + Delafloxacin Moderate
- Calcium carbonate + Delafloxacin Moderate
- Calcium + Delafloxacin Moderate
- Carbonyl iron + Delafloxacin Moderate
- Delafloxacin + Didanosine Moderate
- Delafloxacin + Ferrous fumarate Moderate
Frequently asked questions
Can I take Delafloxacin with Magnesium?
MediHelp rates the interaction as moderate. Delafloxacin and Magnesium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral magnesium salts bind delafloxacin in the gut and reduce its absorption, which may lead to subtherapeutic antibiotic levels and treatment failure.
How serious is the interaction between Delafloxacin and Magnesium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give oral delafloxacin at least 2 hours before or 6 hours after magnesium-containing products.
What other medicines interact with Magnesium?
MediHelp also lists interactions of Magnesium with, for example, Ciprofloxacin, Pancuronium, Rocuronium. The full list is on the Magnesium page.
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