Drug interactions
Delafloxacin + Warfarin
Severity: Moderate
Delafloxacin and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones have been associated with raised INR and bleeding in patients taking warfarin. Delafloxacin has a less well characterised effect, but the class concern applies, and the acute infection itself can alter INR.
What this interaction means in plain words
Delafloxacin and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Delafloxacin belongs to Anti Bacterial; Warfarin belongs to Cardiovascular.
Why it happens
The mechanism is not firmly established; it may involve altered gut flora vitamin K production and possibly reduced warfarin clearance.
What to do
Check INR within a few days of starting delafloxacin and during therapy, adjusting the warfarin dose as needed. Watch for signs of bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Other interactions of Delafloxacin
- Aluminum hydroxide + Delafloxacin Moderate
- Calcium carbonate + Delafloxacin Moderate
- Calcium + Delafloxacin Moderate
- Carbonyl iron + Delafloxacin Moderate
- Delafloxacin + Didanosine Moderate
- Delafloxacin + Ferrous fumarate Moderate
Frequently asked questions
Can I take Delafloxacin with Warfarin?
MediHelp rates the interaction as moderate. Delafloxacin and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones have been associated with raised INR and bleeding in patients taking warfarin. Delafloxacin has a less well characterised effect, but the class concern applies, and the acute infection itself can alter INR.
How serious is the interaction between Delafloxacin and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check INR within a few days of starting delafloxacin and during therapy, adjusting the warfarin dose as needed. Watch for signs of bleeding.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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