Drug interactions
Delamanid + Moxifloxacin
Severity: Major
Delamanid and Moxifloxacin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs prolong the QT interval, so the combination increases the risk of torsades de pointes and serious arrhythmia.
What this interaction means in plain words
Delamanid and Moxifloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Delamanid belongs to Anti Bacterial; Moxifloxacin belongs to Anti Bacterial.
Why it happens
Additive QT prolongation through cardiac repolarization effects.
What to do
Avoid the combination when alternatives exist. If unavoidable, perform frequent ECG monitoring and correct potassium, magnesium and calcium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Delamanid
- Carbamazepine + Delamanid Contraindicated
- Delamanid + Rifampicin Contraindicated
- Delamanid + Ritonavir Major
- Delamanid + Ethambutol Minor
Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Delamanid with Moxifloxacin?
MediHelp rates the interaction as major. Delamanid and Moxifloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs prolong the QT interval, so the combination increases the risk of torsades de pointes and serious arrhythmia.
How serious is the interaction between Delamanid and Moxifloxacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination when alternatives exist. If unavoidable, perform frequent ECG monitoring and correct potassium, magnesium and calcium.
What other medicines interact with Delamanid?
MediHelp also lists interactions of Delamanid with, for example, Carbamazepine, Rifampicin, Ritonavir. The full list is on the Delamanid page.
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