Drug interactions
Demeclocycline + Sucralfate
Severity: Moderate
Demeclocycline and Sucralfate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sucralfate can bind oral tetracyclines such as demeclocycline in the gut and reduce absorption. This may lead to reduced antibacterial efficacy.
What this interaction means in plain words
Demeclocycline and Sucralfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chelation/adsorption of demeclocycline by aluminium in sucralfate, decreasing GI absorption.
What to do
Separate doses by at least 2 hours, giving demeclocycline first. Monitor clinical response to the antibiotic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sucralfate
Frequently asked questions
Can I take Demeclocycline with Sucralfate?
MediHelp rates the interaction as moderate. Demeclocycline and Sucralfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sucralfate can bind oral tetracyclines such as demeclocycline in the gut and reduce absorption. This may lead to reduced antibacterial efficacy.
How serious is the interaction between Demeclocycline and Sucralfate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate doses by at least 2 hours, giving demeclocycline first. Monitor clinical response to the antibiotic.
What other medicines interact with Sucralfate?
MediHelp also lists interactions of Sucralfate with, for example, Ciprofloxacin, Gemifloxacin, Levofloxacin. The full list is on the Sucralfate page.
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