Drug interactions
Denosumab + Imatinib
Severity: Moderate
Denosumab and Imatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib can cause neutropenia and denosumab has been associated with serious infections. Concurrent use may modestly raise infection risk.
What this interaction means in plain words
Denosumab and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Denosumab belongs to Oncology; Imatinib belongs to Oncology.
Why it happens
Additive pharmacodynamic effect: kinase inhibitor-related myelosuppression combined with RANKL inhibition.
What to do
Monitor complete blood counts and clinical signs of infection. Manage infections promptly and adjust imatinib per neutropenia guidance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Denosumab
- Abatacept + Denosumab Moderate
- Adalimumab + Denosumab Moderate
- Alefacept + Denosumab Moderate
- Alemtuzumab + Denosumab Moderate
- Anakinra + Denosumab Moderate
- Azacitidine + Denosumab Moderate
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Denosumab with Imatinib?
MediHelp rates the interaction as moderate. Denosumab and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib can cause neutropenia and denosumab has been associated with serious infections. Concurrent use may modestly raise infection risk.
How serious is the interaction between Denosumab and Imatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and clinical signs of infection. Manage infections promptly and adjust imatinib per neutropenia guidance.
What other medicines interact with Denosumab?
MediHelp also lists interactions of Denosumab with, for example, Abatacept, Adalimumab, Alefacept. The full list is on the Denosumab page.
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