Drug interactions
Denosumab + Paclitaxel
Severity: Moderate
Denosumab and Paclitaxel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paclitaxel causes neutropenia and denosumab has been linked with serious infections including skin infections. Together they may increase infection risk.
What this interaction means in plain words
Denosumab and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Denosumab belongs to Oncology; Paclitaxel belongs to Oncology.
Why it happens
Additive pharmacodynamic effect: taxane myelosuppression plus RANKL inhibition affecting immunity.
What to do
Monitor neutrophil counts and signs of infection, including cellulitis. Treat infections promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Denosumab
- Abatacept + Denosumab Moderate
- Adalimumab + Denosumab Moderate
- Alefacept + Denosumab Moderate
- Alemtuzumab + Denosumab Moderate
- Anakinra + Denosumab Moderate
- Azacitidine + Denosumab Moderate
Other interactions of Paclitaxel
Frequently asked questions
Can I take Denosumab with Paclitaxel?
MediHelp rates the interaction as moderate. Denosumab and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paclitaxel causes neutropenia and denosumab has been linked with serious infections including skin infections. Together they may increase infection risk.
How serious is the interaction between Denosumab and Paclitaxel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neutrophil counts and signs of infection, including cellulitis. Treat infections promptly.
What other medicines interact with Denosumab?
MediHelp also lists interactions of Denosumab with, for example, Abatacept, Adalimumab, Alefacept. The full list is on the Denosumab page.
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