Drug interactions
Denosumab + Pralatrexate
Severity: Moderate
Denosumab and Pralatrexate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pralatrexate causes myelosuppression and mucositis, and denosumab has been linked to serious infections. Together they may increase infection risk.
What this interaction means in plain words
Denosumab and Pralatrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Denosumab belongs to Oncology; Pralatrexate belongs to Oncology.
Why it happens
Additive pharmacodynamic effect: antifolate myelosuppression and mucosal injury plus RANKL inhibition.
What to do
Monitor blood counts and watch for infection and mucositis. Treat infections early.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Denosumab
- Abatacept + Denosumab Moderate
- Adalimumab + Denosumab Moderate
- Alefacept + Denosumab Moderate
- Alemtuzumab + Denosumab Moderate
- Anakinra + Denosumab Moderate
- Azacitidine + Denosumab Moderate
Other interactions of Pralatrexate
Frequently asked questions
Can I take Denosumab with Pralatrexate?
MediHelp rates the interaction as moderate. Denosumab and Pralatrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pralatrexate causes myelosuppression and mucositis, and denosumab has been linked to serious infections. Together they may increase infection risk.
How serious is the interaction between Denosumab and Pralatrexate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and watch for infection and mucositis. Treat infections early.
What other medicines interact with Denosumab?
MediHelp also lists interactions of Denosumab with, for example, Abatacept, Adalimumab, Alefacept. The full list is on the Denosumab page.
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