Drug interactions
Denosumab + Prednisone
Severity: Moderate
Denosumab and Prednisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Denosumab carries a risk of serious infections, and concurrent immunosuppressants such as prednisone may add to that risk. This includes skin, urinary tract, and other bacterial infections. Prednisone also causes bone loss, so the combination is often used intentionally for glucocorticoid-induced osteoporosis.
What this interaction means in plain words
Denosumab and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Denosumab belongs to Oncology; Prednisone belongs to Endocrine.
Why it happens
Additive immunosuppression, with denosumab altering RANKL-mediated immune signaling and prednisone suppressing immune function broadly.
What to do
Counsel patients to report signs of infection early and monitor for infection during therapy. Ensure adequate calcium and vitamin D and monitor serum calcium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Other interactions of Denosumab
- Abatacept + Denosumab Moderate
- Adalimumab + Denosumab Moderate
- Alefacept + Denosumab Moderate
- Alemtuzumab + Denosumab Moderate
- Anakinra + Denosumab Moderate
- Azacitidine + Denosumab Moderate
Frequently asked questions
Can I take Denosumab with Prednisone?
MediHelp rates the interaction as moderate. Denosumab and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Denosumab carries a risk of serious infections, and concurrent immunosuppressants such as prednisone may add to that risk. This includes skin, urinary tract, and other bacterial infections. Prednisone also causes bone loss, so the combination is often used intentionally for glucocorticoid-induced osteoporosis.
How serious is the interaction between Denosumab and Prednisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to report signs of infection early and monitor for infection during therapy. Ensure adequate calcium and vitamin D and monitor serum calcium.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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