Drug interactions
Denosumab + Ustekinumab
Severity: Moderate
Denosumab and Ustekinumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can be associated with serious infections, and denosumab has reported infection risks including skin infections. Combined use may add to infection risk, particularly in immunocompromised patients.
What this interaction means in plain words
Denosumab and Ustekinumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Denosumab belongs to Oncology; Ustekinumab belongs to Gastrointestinal Tract.
Why it happens
Additive effects on immune function through IL-12/23 inhibition and RANKL inhibition.
What to do
Monitor for signs of infection and treat promptly. Reassess therapy if a serious infection occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ustekinumab
- Bcg vaccine live + Ustekinumab Contraindicated
- Typhoid vaccine live + Ustekinumab Contraindicated
- Adalimumab + Ustekinumab Major
- Adenovirus types 4 and 7 live + Ustekinumab Major
- Alefacept + Ustekinumab Major
- Anakinra + Ustekinumab Major
Other interactions of Denosumab
- Abatacept + Denosumab Moderate
- Adalimumab + Denosumab Moderate
- Alefacept + Denosumab Moderate
- Alemtuzumab + Denosumab Moderate
- Anakinra + Denosumab Moderate
- Azacitidine + Denosumab Moderate
Frequently asked questions
Can I take Denosumab with Ustekinumab?
MediHelp rates the interaction as moderate. Denosumab and Ustekinumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can be associated with serious infections, and denosumab has reported infection risks including skin infections. Combined use may add to infection risk, particularly in immunocompromised patients.
How serious is the interaction between Denosumab and Ustekinumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of infection and treat promptly. Reassess therapy if a serious infection occurs.
What other medicines interact with Ustekinumab?
MediHelp also lists interactions of Ustekinumab with, for example, Bcg vaccine live, Typhoid vaccine live, Adalimumab. The full list is on the Ustekinumab page.
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