Drug interactions
Denosumab + Vinblastine
Severity: Moderate
Denosumab and Vinblastine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vinblastine causes myelosuppression and denosumab has been linked to serious infections. Together they may increase infection risk in patients already immunocompromised by cancer or chemotherapy.
What this interaction means in plain words
Denosumab and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Denosumab belongs to Oncology; Vinblastine belongs to Oncology.
Why it happens
Additive pharmacodynamic effect on infection risk: RANKL inhibition by denosumab may affect immune function while vinblastine suppresses bone marrow.
What to do
Monitor for signs of infection and check blood counts regularly during chemotherapy. Treat infections promptly and reconsider denosumab if serious infection occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Denosumab
- Abatacept + Denosumab Moderate
- Adalimumab + Denosumab Moderate
- Alefacept + Denosumab Moderate
- Alemtuzumab + Denosumab Moderate
- Anakinra + Denosumab Moderate
- Azacitidine + Denosumab Moderate
Other interactions of Vinblastine
Frequently asked questions
Can I take Denosumab with Vinblastine?
MediHelp rates the interaction as moderate. Denosumab and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vinblastine causes myelosuppression and denosumab has been linked to serious infections. Together they may increase infection risk in patients already immunocompromised by cancer or chemotherapy.
How serious is the interaction between Denosumab and Vinblastine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of infection and check blood counts regularly during chemotherapy. Treat infections promptly and reconsider denosumab if serious infection occurs.
What other medicines interact with Denosumab?
MediHelp also lists interactions of Denosumab with, for example, Abatacept, Adalimumab, Alefacept. The full list is on the Denosumab page.
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