Drug interactions
Desflurane + Desipramine
Severity: Moderate
Desflurane and Desipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Volatile anaesthetics like desflurane cause CNS depression and can prolong the QT interval, while tricyclics sensitise the heart to arrhythmias and alter blood pressure responses. Perioperatively the combination may cause hypotension, arrhythmia and exaggerated sedation.
What this interaction means in plain words
Desflurane and Desipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desflurane belongs to Central Nervous System; Desipramine belongs to Central Nervous System.
Why it happens
Additive CNS depression, QT prolongation and cardiovascular effects.
What to do
Inform the anaesthetist about tricyclic use and monitor ECG and blood pressure intraoperatively; avoid sympathomimetic vasopressors that could provoke exaggerated pressor responses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Desflurane and Desipramine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Other interactions of Desflurane
Frequently asked questions
Can I take Desflurane with Desipramine?
MediHelp rates the interaction as moderate. Desflurane and Desipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Volatile anaesthetics like desflurane cause CNS depression and can prolong the QT interval, while tricyclics sensitise the heart to arrhythmias and alter blood pressure responses. Perioperatively the combination may cause hypotension, arrhythmia and exaggerated sedation.
How serious is the interaction between Desflurane and Desipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anaesthetist about tricyclic use and monitor ECG and blood pressure intraoperatively; avoid sympathomimetic vasopressors that could provoke exaggerated pressor responses.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
