Drug interactions
Desflurane + Deutetrabenazine
Severity: Moderate
Desflurane and Deutetrabenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Desflurane can prolong the QT interval, and deutetrabenazine produces a small QT effect at higher exposures. Used together, this adds modest arrhythmic risk, especially with bradycardia, low potassium or magnesium, or other QT-prolonging drugs. Deutetrabenazine also adds sedation.
What this interaction means in plain words
Desflurane and Deutetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desflurane belongs to Central Nervous System; Deutetrabenazine belongs to Central Nervous System.
Why it happens
Additive effects on cardiac repolarization, with additive CNS depression.
What to do
Correct electrolytes and review baseline ECG in patients with QT risk factors. Monitor ECG during anesthesia and avoid additional QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desflurane
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Desflurane with Deutetrabenazine?
MediHelp rates the interaction as moderate. Desflurane and Deutetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Desflurane can prolong the QT interval, and deutetrabenazine produces a small QT effect at higher exposures. Used together, this adds modest arrhythmic risk, especially with bradycardia, low potassium or magnesium, or other QT-prolonging drugs. Deutetrabenazine also adds sedation.
How serious is the interaction between Desflurane and Deutetrabenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct electrolytes and review baseline ECG in patients with QT risk factors. Monitor ECG during anesthesia and avoid additional QT-prolonging drugs.
What other medicines interact with Desflurane?
MediHelp also lists interactions of Desflurane with, for example, Amisulpride, Anagrelide, Arsenic trioxide. The full list is on the Desflurane page.
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