Drug interactions
Desflurane + Fostemsavir
Severity: Minor
Desflurane and Fostemsavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fostemsavir has produced QT prolongation at supratherapeutic doses, and volatile anesthetics such as desflurane can also prolong the QT interval. Together they could add to arrhythmia risk, although at recommended fostemsavir doses the effect is small.
What this interaction means in plain words
Desflurane and Fostemsavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Desflurane belongs to Central Nervous System; Fostemsavir belongs to Anti Virals.
Why it happens
Additive prolongation of cardiac repolarization (QTc) by both agents.
What to do
At standard fostemsavir doses no change is usually needed; check baseline ECG and electrolytes in patients with other QT risk factors. Correct potassium and magnesium before anesthesia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desflurane
Other interactions of Fostemsavir
- Apalutamide + Fostemsavir Contraindicated
- Carbamazepine + Fostemsavir Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Fostemsavir + Phenytoin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Desflurane with Fostemsavir?
MediHelp rates the interaction as minor. Desflurane and Fostemsavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fostemsavir has produced QT prolongation at supratherapeutic doses, and volatile anesthetics such as desflurane can also prolong the QT interval. Together they could add to arrhythmia risk, although at recommended fostemsavir doses the effect is small.
How serious is the interaction between Desflurane and Fostemsavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: At standard fostemsavir doses no change is usually needed; check baseline ECG and electrolytes in patients with other QT risk factors. Correct potassium and magnesium before anesthesia.
What other medicines interact with Desflurane?
MediHelp also lists interactions of Desflurane with, for example, Amisulpride, Anagrelide, Arsenic trioxide. The full list is on the Desflurane page.
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