Drug interactions
Desflurane + Histrelin
Severity: Moderate
Desflurane and Histrelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Histrelin, a GnRH agonist, can prolong the QT interval through androgen deprivation, and desflurane may add to this. The clinical risk is modest, mainly in patients with other QT risk factors.
What this interaction means in plain words
Desflurane and Histrelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desflurane belongs to Central Nervous System; Histrelin belongs to Musculoskeletal.
Why it happens
Additive QT prolongation; androgen deprivation therapy is associated with repolarization changes.
What to do
Review baseline QTc and electrolytes before anesthesia. Monitor the ECG perioperatively in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desflurane
Other interactions of Histrelin
- Amiodarone + Histrelin Major
- Anagrelide + Histrelin Major
- Histrelin + Thioridazine Major
- Alfuzosin + Histrelin Moderate
- Amisulpride + Histrelin Moderate
- Asenapine + Histrelin Moderate
Frequently asked questions
Can I take Desflurane with Histrelin?
MediHelp rates the interaction as moderate. Desflurane and Histrelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Histrelin, a GnRH agonist, can prolong the QT interval through androgen deprivation, and desflurane may add to this. The clinical risk is modest, mainly in patients with other QT risk factors.
How serious is the interaction between Desflurane and Histrelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review baseline QTc and electrolytes before anesthesia. Monitor the ECG perioperatively in patients with other QT risk factors.
What other medicines interact with Desflurane?
MediHelp also lists interactions of Desflurane with, for example, Amisulpride, Anagrelide, Arsenic trioxide. The full list is on the Desflurane page.
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