Drug interactions
Desflurane + Linezolid
Severity: Minor
Desflurane and Linezolid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Linezolid is an MAO inhibitor and MAOIs may interact with anesthetics, with possible hemodynamic instability during anesthesia. The evidence for desflurane specifically is limited and largely theoretical.
What this interaction means in plain words
Desflurane and Linezolid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Desflurane belongs to Central Nervous System; Linezolid belongs to Anti Bacterial.
Why it happens
Possible pharmacodynamic interaction via MAO inhibition and altered sympathetic responses; not well established.
What to do
Tell the anesthesia team about linezolid use and monitor blood pressure and heart rate during anesthesia. Avoid indirect-acting sympathomimetic vasopressors if possible.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Other interactions of Desflurane
Frequently asked questions
Can I take Desflurane with Linezolid?
MediHelp rates the interaction as minor. Desflurane and Linezolid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Linezolid is an MAO inhibitor and MAOIs may interact with anesthetics, with possible hemodynamic instability during anesthesia. The evidence for desflurane specifically is limited and largely theoretical.
How serious is the interaction between Desflurane and Linezolid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Tell the anesthesia team about linezolid use and monitor blood pressure and heart rate during anesthesia. Avoid indirect-acting sympathomimetic vasopressors if possible.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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