Drug interactions
Desflurane + Maprotiline
Severity: Moderate
Desflurane and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Volatile anesthetics such as desflurane can prolong the QT interval, and maprotiline may add to this during anesthesia. Tricyclic-type antidepressants can also cause arrhythmias and hypotension under anesthesia.
What this interaction means in plain words
Desflurane and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desflurane belongs to Central Nervous System; Maprotiline belongs to Central Nervous System.
Why it happens
Additive effects on cardiac repolarization and autonomic cardiovascular responses.
What to do
Inform the anesthesia team of maprotiline use and obtain a preoperative ECG. Keep electrolytes normal and monitor the ECG and blood pressure continuously during anesthesia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Desflurane
Frequently asked questions
Can I take Desflurane with Maprotiline?
MediHelp rates the interaction as moderate. Desflurane and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Volatile anesthetics such as desflurane can prolong the QT interval, and maprotiline may add to this during anesthesia. Tricyclic-type antidepressants can also cause arrhythmias and hypotension under anesthesia.
How serious is the interaction between Desflurane and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team of maprotiline use and obtain a preoperative ECG. Keep electrolytes normal and monitor the ECG and blood pressure continuously during anesthesia.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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