Drug interactions
Desflurane + Nadolol
Severity: Moderate
Desflurane and Nadolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Volatile anesthetics depress myocardial contractility and vascular tone, and nadolol blunts compensatory sympathetic responses. The combination may cause more pronounced hypotension and bradycardia.
What this interaction means in plain words
Desflurane and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desflurane belongs to Central Nervous System; Nadolol belongs to Cardiovascular.
Why it happens
Additive cardiovascular depression from beta-blockade and volatile anesthetic vasodilation and myocardial depression.
What to do
Generally continue beta-blocker perioperatively but monitor blood pressure and heart rate continuously. Have vasopressors and anticholinergics available to treat hypotension or bradycardia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desflurane
Other interactions of Nadolol
Frequently asked questions
Can I take Desflurane with Nadolol?
MediHelp rates the interaction as moderate. Desflurane and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Volatile anesthetics depress myocardial contractility and vascular tone, and nadolol blunts compensatory sympathetic responses. The combination may cause more pronounced hypotension and bradycardia.
How serious is the interaction between Desflurane and Nadolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Generally continue beta-blocker perioperatively but monitor blood pressure and heart rate continuously. Have vasopressors and anticholinergics available to treat hypotension or bradycardia.
What other medicines interact with Desflurane?
MediHelp also lists interactions of Desflurane with, for example, Amisulpride, Anagrelide, Arsenic trioxide. The full list is on the Desflurane page.
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