Drug interactions
Desflurane + Procarbazine
Severity: Moderate
Desflurane and Procarbazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine has weak monoamine oxidase inhibiting activity and CNS depressant effects, and may potentiate anesthetic agents and other CNS depressants. Hemodynamic instability and enhanced sedation are possible during general anesthesia.
What this interaction means in plain words
Desflurane and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desflurane belongs to Central Nervous System; Procarbazine belongs to Oncology.
Why it happens
Additive CNS depression and weak MAO inhibition that may alter cardiovascular responses; the interaction is not well characterized.
What to do
Alert the anesthesia team to procarbazine therapy and monitor blood pressure, heart rate and sedation depth. Avoid indirect-acting sympathomimetics and treat hypotension with direct-acting agents.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desflurane
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Desflurane with Procarbazine?
MediHelp rates the interaction as moderate. Desflurane and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Procarbazine has weak monoamine oxidase inhibiting activity and CNS depressant effects, and may potentiate anesthetic agents and other CNS depressants. Hemodynamic instability and enhanced sedation are possible during general anesthesia.
How serious is the interaction between Desflurane and Procarbazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Alert the anesthesia team to procarbazine therapy and monitor blood pressure, heart rate and sedation depth. Avoid indirect-acting sympathomimetics and treat hypotension with direct-acting agents.
What other medicines interact with Desflurane?
MediHelp also lists interactions of Desflurane with, for example, Amisulpride, Anagrelide, Arsenic trioxide. The full list is on the Desflurane page.
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