Drug interactions
Desflurane + Thioridazine
Severity: Moderate
Desflurane and Thioridazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thioridazine can lower the anesthetic requirement and add to the hypotensive and depressant effects of inhaled anesthetics. It also prolongs the QT interval, and volatile anesthetics such as desflurane can further affect ventricular repolarization. Perioperative hypotension and arrhythmia are therefore more likely.
What this interaction means in plain words
Desflurane and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desflurane belongs to Central Nervous System; Thioridazine belongs to Central Nervous System.
Why it happens
Additive CNS and cardiovascular depression, with additive effects on QT interval.
What to do
Inform the anesthesia team of thioridazine use and check a pre-operative ECG and electrolytes. Titrate anesthetic depth carefully and monitor ECG and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Other interactions of Desflurane
Frequently asked questions
Can I take Desflurane with Thioridazine?
MediHelp rates the interaction as moderate. Desflurane and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thioridazine can lower the anesthetic requirement and add to the hypotensive and depressant effects of inhaled anesthetics. It also prolongs the QT interval, and volatile anesthetics such as desflurane can further affect ventricular repolarization. Perioperative hypotension and arrhythmia are therefore more likely.
How serious is the interaction between Desflurane and Thioridazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team of thioridazine use and check a pre-operative ECG and electrolytes. Titrate anesthetic depth carefully and monitor ECG and blood pressure.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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