Drug interactions
Desflurane + Voclosporin
Severity: Moderate
Desflurane and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin has been associated with QT prolongation at supratherapeutic exposures, and volatile anesthetics can also lengthen the QT interval. The additive effect may increase arrhythmia risk, although the clinical significance at usual doses is uncertain.
What this interaction means in plain words
Desflurane and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desflurane belongs to Central Nervous System; Voclosporin belongs to Miscellaneous.
Why it happens
Possible additive QTc prolongation.
What to do
Check electrolytes and a baseline ECG before anesthesia and monitor the ECG intraoperatively. Also be aware of the impact of renal function on voclosporin exposure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desflurane
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Desflurane with Voclosporin?
MediHelp rates the interaction as moderate. Desflurane and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voclosporin has been associated with QT prolongation at supratherapeutic exposures, and volatile anesthetics can also lengthen the QT interval. The additive effect may increase arrhythmia risk, although the clinical significance at usual doses is uncertain.
How serious is the interaction between Desflurane and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check electrolytes and a baseline ECG before anesthesia and monitor the ECG intraoperatively. Also be aware of the impact of renal function on voclosporin exposure.
What other medicines interact with Desflurane?
MediHelp also lists interactions of Desflurane with, for example, Amisulpride, Anagrelide, Arsenic trioxide. The full list is on the Desflurane page.
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