Drug interactions
Desflurane + Ziprasidone
Severity: Moderate
Desflurane and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Volatile anesthetics such as desflurane can prolong the QT interval, and ziprasidone does so as well, so the perioperative risk of torsades de pointes may increase. Anesthesia-related electrolyte shifts and bradycardia may add to this risk.
What this interaction means in plain words
Desflurane and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desflurane belongs to Central Nervous System; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive QT prolongation through effects on cardiac repolarization.
What to do
Check a baseline ECG and correct potassium and magnesium before anesthesia. Monitor the ECG continuously during and after the procedure and tell the anesthesia team about ziprasidone use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Other interactions of Desflurane
Frequently asked questions
Can I take Desflurane with Ziprasidone?
MediHelp rates the interaction as moderate. Desflurane and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Volatile anesthetics such as desflurane can prolong the QT interval, and ziprasidone does so as well, so the perioperative risk of torsades de pointes may increase. Anesthesia-related electrolyte shifts and bradycardia may add to this risk.
How serious is the interaction between Desflurane and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and correct potassium and magnesium before anesthesia. Monitor the ECG continuously during and after the procedure and tell the anesthesia team about ziprasidone use.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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