Drug interactions
Desipramine + Dexmedetomidine
Severity: Moderate
Desipramine and Dexmedetomidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexmedetomidine is a sedative alpha-2 agonist that can cause bradycardia and hypotension, and desipramine adds CNS depression and may alter cardiovascular responses. Sedation may be greater than expected.
What this interaction means in plain words
Desipramine and Dexmedetomidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desipramine belongs to Central Nervous System; Dexmedetomidine belongs to Central Nervous System.
Why it happens
Additive CNS depression and cardiovascular effects.
What to do
Titrate dexmedetomidine to effect with reduced initial dosing and monitor sedation depth, heart rate and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Other interactions of Dexmedetomidine
Frequently asked questions
Can I take Desipramine with Dexmedetomidine?
MediHelp rates the interaction as moderate. Desipramine and Dexmedetomidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexmedetomidine is a sedative alpha-2 agonist that can cause bradycardia and hypotension, and desipramine adds CNS depression and may alter cardiovascular responses. Sedation may be greater than expected.
How serious is the interaction between Desipramine and Dexmedetomidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate dexmedetomidine to effect with reduced initial dosing and monitor sedation depth, heart rate and blood pressure.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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