Drug interactions
Desipramine + Dicyclomine
Severity: Moderate
Desipramine and Dicyclomine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Desipramine has antimuscarinic activity, although weaker than some other tricyclics. Together with dicyclomine, it may cause additive dry mouth, constipation, urinary retention and cognitive effects.
What this interaction means in plain words
Desipramine and Dicyclomine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desipramine belongs to Central Nervous System; Dicyclomine belongs to Respiratory.
Why it happens
Additive muscarinic receptor blockade.
What to do
Monitor for anticholinergic effects, especially in older patients, and reduce doses or choose alternatives if bothersome. Avoid in patients with urinary retention or narrow-angle glaucoma.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Desipramine and Dicyclomine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Dicyclomine
- Clozapine + Dicyclomine Major
- Dicyclomine + Henbane Major
- Dicyclomine + Imipramine Major
- Dicyclomine + Pramlintide Major
- Abobotulinumtoxina + Dicyclomine Moderate
- Aclidinium + Dicyclomine Moderate
Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Desipramine with Dicyclomine?
MediHelp rates the interaction as moderate. Desipramine and Dicyclomine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Desipramine has antimuscarinic activity, although weaker than some other tricyclics. Together with dicyclomine, it may cause additive dry mouth, constipation, urinary retention and cognitive effects.
How serious is the interaction between Desipramine and Dicyclomine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects, especially in older patients, and reduce doses or choose alternatives if bothersome. Avoid in patients with urinary retention or narrow-angle glaucoma.
What other medicines interact with Dicyclomine?
MediHelp also lists interactions of Dicyclomine with, for example, Clozapine, Henbane, Imipramine. The full list is on the Dicyclomine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
