Drug interactions
Desipramine + Difelikefalin
Severity: Moderate
Desipramine and Difelikefalin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Difelikefalin can cause somnolence and dizziness, and desipramine is also sedating. Together they may increase drowsiness and the risk of falls, especially in dialysis patients who are often frail.
What this interaction means in plain words
Desipramine and Difelikefalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desipramine belongs to Central Nervous System; Difelikefalin belongs to Dermatology.
Why it happens
Additive CNS depressant effects; difelikefalin acts on peripheral kappa opioid receptors with some central effects, and desipramine has sedative properties.
What to do
Monitor for excessive drowsiness, dizziness and falls after starting or changing doses. Advise patients to avoid driving until the combined effect is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Other interactions of Difelikefalin
- Acetazolamide + Difelikefalin Moderate
- Alprazolam + Difelikefalin Moderate
- Amantadine + Difelikefalin Moderate
- Amitriptyline + Difelikefalin Moderate
- Amobarbital + Difelikefalin Moderate
- Asenapine + Difelikefalin Moderate
Frequently asked questions
Can I take Desipramine with Difelikefalin?
MediHelp rates the interaction as moderate. Desipramine and Difelikefalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Difelikefalin can cause somnolence and dizziness, and desipramine is also sedating. Together they may increase drowsiness and the risk of falls, especially in dialysis patients who are often frail.
How serious is the interaction between Desipramine and Difelikefalin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive drowsiness, dizziness and falls after starting or changing doses. Advise patients to avoid driving until the combined effect is known.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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