Drug interactions
Desipramine + Eliglustat
Severity: Major
Desipramine and Eliglustat: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat is metabolized mainly by CYP2D6 and to a lesser extent CYP3A4. Desipramine is a CYP2D6 substrate with weak to moderate inhibitory effect, and both agents can affect cardiac conduction, so eliglustat exposure and the risk of PR, QTc and QRS prolongation may increase.
What this interaction means in plain words
Desipramine and Eliglustat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Desipramine belongs to Central Nervous System; Eliglustat belongs to Miscellaneous.
Why it happens
Competitive CYP2D6 interaction increasing eliglustat exposure, with additive effects on cardiac conduction.
What to do
Avoid the combination where possible, particularly in patients with cardiac disease. If used together, monitor ECG and consider eliglustat dose adjustment per labeling.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Desipramine with Eliglustat?
MediHelp rates the interaction as major. Desipramine and Eliglustat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eliglustat is metabolized mainly by CYP2D6 and to a lesser extent CYP3A4. Desipramine is a CYP2D6 substrate with weak to moderate inhibitory effect, and both agents can affect cardiac conduction, so eliglustat exposure and the risk of PR, QTc and QRS prolongation may increase.
How serious is the interaction between Desipramine and Eliglustat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, particularly in patients with cardiac disease. If used together, monitor ECG and consider eliglustat dose adjustment per labeling.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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