Drug interactions
Desipramine + Lurasidone
Severity: Moderate
Desipramine and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause orthostatic hypotension through alpha-1 adrenergic blockade, so combined use may produce dizziness and falls. Sedation may also be additive.
What this interaction means in plain words
Desipramine and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desipramine belongs to Central Nervous System; Lurasidone belongs to Central Nervous System.
Why it happens
Additive alpha-1 adrenergic antagonism and CNS depression.
What to do
Monitor blood pressure, especially on standing, after starting or changing doses. Titrate slowly and counsel patients to rise gradually.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Desipramine with Lurasidone?
MediHelp rates the interaction as moderate. Desipramine and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause orthostatic hypotension through alpha-1 adrenergic blockade, so combined use may produce dizziness and falls. Sedation may also be additive.
How serious is the interaction between Desipramine and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, especially on standing, after starting or changing doses. Titrate slowly and counsel patients to rise gradually.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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