Drug interactions
Desipramine + Macimorelin
Severity: Moderate
Desipramine and Macimorelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Macimorelin has a modest QT-prolonging effect and desipramine can also prolong QT, so combined use may increase the risk of torsades de pointes. Macimorelin is a single-dose diagnostic agent.
What this interaction means in plain words
Desipramine and Macimorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desipramine belongs to Central Nervous System; Macimorelin belongs to Endocrine.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Delay macimorelin testing until desipramine has been adequately washed out where clinically feasible, or defer the test.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Other interactions of Macimorelin
Frequently asked questions
Can I take Desipramine with Macimorelin?
MediHelp rates the interaction as moderate. Desipramine and Macimorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Macimorelin has a modest QT-prolonging effect and desipramine can also prolong QT, so combined use may increase the risk of torsades de pointes. Macimorelin is a single-dose diagnostic agent.
How serious is the interaction between Desipramine and Macimorelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Delay macimorelin testing until desipramine has been adequately washed out where clinically feasible, or defer the test.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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