Drug interactions
Desipramine + Mirabegron
Severity: Moderate
Desipramine and Mirabegron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Desipramine is largely cleared by CYP2D6, and mirabegron inhibition of this enzyme can increase its plasma levels. This may produce anticholinergic effects, tachycardia, conduction changes and other tricyclic toxicity.
What this interaction means in plain words
Desipramine and Mirabegron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desipramine belongs to Central Nervous System; Mirabegron belongs to Genitourinary.
Why it happens
Mirabegron inhibits CYP2D6, decreasing desipramine clearance.
What to do
Monitor heart rate, ECG and anticholinergic symptoms, and consider checking desipramine levels. Lower the desipramine dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirabegron
- Digoxin + Mirabegron Major
- Flecainide + Mirabegron Major
- Mirabegron + Propafenone Major
- Mirabegron + Thioridazine Major
- Amitriptyline + Mirabegron Moderate
- Amoxapine + Mirabegron Moderate
Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Desipramine with Mirabegron?
MediHelp rates the interaction as moderate. Desipramine and Mirabegron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Desipramine is largely cleared by CYP2D6, and mirabegron inhibition of this enzyme can increase its plasma levels. This may produce anticholinergic effects, tachycardia, conduction changes and other tricyclic toxicity.
How serious is the interaction between Desipramine and Mirabegron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, ECG and anticholinergic symptoms, and consider checking desipramine levels. Lower the desipramine dose if needed.
What other medicines interact with Mirabegron?
MediHelp also lists interactions of Mirabegron with, for example, Digoxin, Flecainide, Propafenone. The full list is on the Mirabegron page.
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