Drug interactions
Desipramine + OnabotulinumtoxinA
Severity: Minor
Desipramine and OnabotulinumtoxinA: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drugs with anticholinergic activity may add to the effects of botulinum toxin, possibly leading to excessive weakness or systemic anticholinergic effects. The clinical significance is likely small at standard doses but is noted in the labeling.
What this interaction means in plain words
Desipramine and OnabotulinumtoxinA have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Desipramine belongs to Central Nervous System; OnabotulinumtoxinA belongs to Musculoskeletal.
Why it happens
Additive anticholinergic and neuromuscular effects, as suggested by labeling.
What to do
Watch for unusual muscle weakness, swallowing or breathing difficulty and anticholinergic symptoms after injection. Use the lowest effective toxin dose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Other interactions of OnabotulinumtoxinA
Frequently asked questions
Can I take Desipramine with OnabotulinumtoxinA?
MediHelp rates the interaction as minor. Desipramine and OnabotulinumtoxinA have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Drugs with anticholinergic activity may add to the effects of botulinum toxin, possibly leading to excessive weakness or systemic anticholinergic effects. The clinical significance is likely small at standard doses but is noted in the labeling.
How serious is the interaction between Desipramine and OnabotulinumtoxinA?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Watch for unusual muscle weakness, swallowing or breathing difficulty and anticholinergic symptoms after injection. Use the lowest effective toxin dose.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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